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Truman was never asked or told about the demonstration option. It is clear that General Groves and the military never gave it much thought. But the Secretary of War did take it serious enough that he asked a small advisory committee of scientists to give him their thoughts on the matter. A Scientific Panel, composed of J. Robert Oppenheimer, Arthur Compton, Enrico Fermi, and Ernest Lawrence, weighed in on the matter formally, concluding that : “ we can propose no technical demonstration likely to bring an end to the war; we see no acceptable alternative to direct military use.” 1

“Recommendations on the Immediate Use of Atomic Weapons,” by the Scientific Panel of the Interim Committee, June 16, 1945. The full report (which also discusses the possibility of the H-bomb and many other things) is extremely interesting, as well — Vans Men’s Mn Asher LowTop Sneakers Beige Washed Canvas Cornstalk official for sale big sale for sale cheap sale newest ikI9HfZz
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I find this a curious conclusion for a few reasons. For one thing, are these four scientists really the best experts to evaluate this question? No offense, they were smart guys, but they are not experts in psychological warfare, Japanese political thought, much less privy to intercepted intelligence about what the Japanese high command was thinking at this time. That four physicists saw no “acceptable alternative” could just be a reflective of their own narrowness, and their opinion sought in part just to have it on the record that while some scientists on the project were uncomfortable with the idea of a no-warning first use, others at the top were acceptingof it.

But that aside, here’s the other fun question to ponder: were they actually unanimous in their position? That is, did these four physicists actually agree on this question? There is evidence that they did not. The apparent dissenter was an unlikely one, the most conservative member of the group: Ernest Lawrence. After the bombing of Hiroshima, Lawrence apparently told his friend, the physicist Karl Darrow, that he had been in favor of demonstration. Darrow put this into writing on August 9, 1945, to preserve it for posterity should Lawrence come under criticism later. In Darrow’s recollection, Lawrence debated it with the other scientists for “about an hour” — a long-enough time to make it seem contentious. On August 17, after the bomb had “worked” to secure the peace, Lawrence wrote back to Darrow, somewhat denying this account, saying that it was maybe only tenminutes of discussion. Lawrence, in this later account, credits Oppenheimer as being the hardest pusher for the argument that unless the demonstration took out a city, it wouldn’t be compelling. I’m not sure I completely believe Lawrence’s later recant, both because Darrow seemed awfully convinced of his recollection andbecause so much changed on how the bomb was perceived after the Japanese surrendered, but it is all an interesting hint as some of the subtleties of this disagreement that get lost from the final documents alone. In any case, I don’t know which is more problematic: that they debated for an hour and after all that, concluded it was necessary, or that they spent no more than tenminutes on the question. 2

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TABLE 2.

Postprandial incremental area under the curve above fasting values for cholesterol, triglycerides, apo B-48, and apo B-100 in plasma lipoproteins in the type 2 diabetic patients and the nondiabetic controls

Values are the mean ± sem . Conversion to Systeme International units for cholesterol, mg/dl: 38.6 = mmol/liter; for triglycerides, mg/dl: 88.5 = mmol/liter.

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The postprandial responses of apo B-48 and apo B-100 in the chylomicron fraction are shown in Fig. 2 and, as incremental areas, in Table 2 . The response to the meal was small and in any case similar between diabetic patients and control subjects.

Triglycerides, cholesterol, apo B-48, and apo B-100 in the large VLDL are shown in Fig. 3 and as incremental areas in Table 2 . Triglycerides and cholesterol were higher at fasting in diabetic patients compared with controls and remained higher during the entire postprandial period; the difference was more evident in the last part of the curve, with still increasing values in the diabetic patients even 6 h after the meal. The incremental areas for both triglycerides and cholesterol were more than doubled in diabetic patients compared with controls. The concentrations of apo B-48 and apo B-100 in large VLDL were also higher in the diabetic patients compared with the controls at different time points of the postprandial curve. The apo B-100 incremental area was markedly higher in the diabetic patients compared with the controls (65.5 ± 11.5 vs. 12.4 ± 1.8 mg/liter·h; P < 0.05). Equally higher was apo B-48 incremental area (7.08 ± 2.65 vs. 1.17 ± 0.88 mg/liter·h; P < 0.05).

F ig . 3.
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Concentrations of triglyceride, cholesterol, apo B-48, and apo B-100 in plasma large VLDL (Sf 60–400) before and after a standard meal in patients with type 2 diabetes and nondiabetic controls (mean ± sem ; by ANOVA for repeated measures, < 0.05; by test, *, < 0.05 control). Conversion to Systeme International units for cholesterol, mg/dl : 38.6 = mmol/liter; for triglycerides, mg/dl: 88.5 = mmol/liter.

F ig . 3.
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Concentrations of triglyceride, cholesterol, apo B-48, and apo B-100 in plasma large VLDL (Sf 60–400) before and after a standard meal in patients with type 2 diabetes and nondiabetic controls (mean ± sem ; by ANOVA for repeated measures, < 0.05; by test, *, < 0.05 control). Conversion to Systeme International units for cholesterol, mg/dl : 38.6 = mmol/liter; for triglycerides, mg/dl: 88.5 = mmol/liter.

Incremental areas for all the components of small VLDL are shown in Table 2 . There were no differences between diabetic patients and control subjects except for apo B-48, whose postprandial incremental area was double in diabetic patients compared with controls (1.77 ± 0.88 vs. 0.88 ± 0.44 mg/liter·h), but the difference was not statistically significant.

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